Day: April 1, 2020

Bicycle Therapeutics partners with Roche

Bicycle Therapeutics, a Cambridge, UK-based biotech, developing proprietary bicyclic peptides has attracted the attention of Roche subsidiary, Genentech. The two companies agreed a collaboration agreement, with Bicycle receiving $30m (€27.4m) in an upfront fee and eligible for a further $1.7bn (€1.55bn) dependent upon milestones met.

The focus will be on the development of small molecules aimed at immuno-oncology (IO) targets. A spokesperson for Bicycle told us that this will allow the company to expand its footprint in the IO space.

When asked in particular what targets would be worked on, the spokesperson only confirmed that they are ‘well-known’ targets that Genentech believes are “particularly well-suited to Bicycle technology.”

Bicyclic peptides are synthetic short peptides constrained to form two loops. According to the company, they combine the pharmacology of a biologic with the pharmacokinetic properties of a small molecule.

In terms of what advantages this may confer, the spokesperson explained

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VW Transporter Turns 70 As The Longest-Surviving Commercial Vehicle

When you think about vehicles that have stood out the test of time, the first on your list would probably the Chevrolet Suburban, which entered production in 1935 and currently the longest-surviving vehicle nameplate in the world. The Ford F-Series trucks will also be a likely candidate, dating back to 1948 when the first of the F-Series pickup family first appeared.

The VW Beetle could have been also part of the list, dating back to 1949 – if only the German marque didn’t decide to ax the name recently. However, there’s another VW that have stood the test of time, and it’s the Transporter.

With 13 million units sold worldwide, the VW Transporter is officially celebrating its 70th birthday and currently stands as the longest-running commercial vehicle nameplate. Now on its sixth generation, the very first Transporter rolled off the Wolfsburg production line on March 8, 1950. It

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AERA – Home

Information on some of the help available for small businesses.

​We are considered essential operations by the federal government, specifically in support of the transportation/logistics sector. You can reach us by phone, fax and email during our regular hours, 7am to 6pm CST, Monday-Friday.

Staying home? All of our previously recorded webinars are available for viewing any time!

Save the date for a conference near you! Exhibitor registration information is now available and attendee information will be coming soon!

IMPORTANT UPDATES: The conference hosted by Scat originally scheduled for May 2 has been postponed due to the COVID-19 outbreak. A new date will be announced when it has been determined. The conference hosted by Hastings Piston Rings originally scheduled for June 19 has been canceled.

Anyone who joins or renews their AERA membership has a chance to win products from our Associate Members throughout the year!

AERA boasts thousands of
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Physical distancing rules lead to boom for Halifax bicycle shop

A bicycle shop in Halifax says business is booming as people look for ways to stay active and keep their distance from others amid the COVID-19 pandemic.

Cyclesmith saw a 42 per cent increase in sales in the first half of March compared to the year before.

“If we’ve been cooped up for two weeks in self-isolation, then we can get out for a bike ride and we get the fresh air and stuff, and we don’t have to be on top of each other,” said owner Andrew Feenstra. 

As of Tuesday, there are 147 confirmed cases of COVID-19 in Nova Scotia.

Cyclesmith has adopted a long list of changes to keep staff and customers safe.

Customers at Cyclesmith in Halifax have to ring a doorbell to be served at the store to make sure everyone respects physical distancing procedures. (Craig Paisley/CBC)

The front door is now locked, and customers

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